Publications

Theodore B. Verhey†, Aaron Gillmor, Varsha Thoppey Manoharan, David C. Schriemer, Sorana Morrissy*, mosaicMPI: a framework for modular data integration across cohorts and -omics modalities. bioRxiv . | DOI : 10.1101/2023.08.18.553919

Varsha Thoppey Manoharan†, Aly Abdelkareem, Samuel Brown, Aaron Gillmor, Courtney Hall, Heewon Seo, Kiran Narta, Sean Grewal, Ngoc Ha Dang, Bo Young Ahn, Kata Otz, Xueqing Lun, Laura Mah, Franz Zemp, Douglas Mahoney, Donna L. Senger, Jennifer A. Chan, A. Sorana Morrissy*, Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma. bioRxiv . | DOI : 10.1101/2023.12.05.570149

Tatari N, Khan S, Livingstone J, Zhai K, Mckenna D, Ignatchenko V, Chokshi C, Gwynne WD, Singh M, Revill S, Mikolajewicz N, Zhu C, Chan J, Hawkins C, Lu JQ, Provias JP, Ask K, Morrissy S, Brown S, Weiss T, Weller M, Han H, Greenspoon JN, Moffat J, Venugopal C, Boutros PC, Singh SK, Kislinger T., The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers. Acta Neuropathologica 2022;144(6):1127-1142. | PMID: 36178522 | DOI : 10.1007/s00401-022-02506-4

Sinha S, Satpathy AT, Zhou W, Hongkai J, Stratton JA, Jaffer A, Bhalis N, Morrissy S, Biernaskie J., Profiling Chromatin Accessibility at Single-cell Resolution. Genomics Proteomics Bioinformatics 2021;19(2):172-190. | PMID: 33581341 | DOI : 10.1016/j.gpb.2020.06.010

Nikolic A, Singhal D, Ellestad K, Johnston M, Shen Y, Gillmor A, Morrissy S, Cairncross JG, Jones S, Lupien M, Chan JA, Neri P, Bahlis N, Gallo M., Copy-scAT: Deconvoluting single-cell chromatin accessibility of genetic subclones in cancer. Science Advances 2021;7(42):eabg6045. | PMID: 34644115 | DOI : 10.1126/sciadv.abg6045

Eszlinger M, Khalil M, Gillmor AH, Huang H, Stewardson P, McIntyre JB, Morrissy S, Paschke R., Histology-based molecular profiling improves mutation detection for advanced thyroid cancer. Genes Chromosomes Cancer 2021;60(8):531-545. | PMID: 33749950 | DOI : 10.1002/gcc.22949

Skowron P†, Farooq H†, Cavalli FMG†, Morrissy AS†, Ly M, Hendrikse LD, Wang EY, Djambazian H, Zhu H, Mungall KL, Trinh QM, Zheng T, Shizhong D, Stucklin AG, Vladoiu MC, Fong V, Holgado BL, Nor C, Wu X, Abd-Rabbo D, Wang YC, Luu B, Suarez RA, Rastan A, Lee JJY, Zhang XY, Daniels C, Dirks P, Malkin D, Bouffet E, Bérubé P, Tabori U, Loukides J, Doz F, O’Delattre OO, Ayrault O, Kim S-K, Meyronet D, Grajkowska WA, Carlotti CG, de Torres C, Mora J, Eberhart CG, Van Meir CG, Kumabe T, French PJ, Kros JM, Jabado N, Lach B, Pollack IF, Hamilton RL, Nageswara Rao AA, Giannini C, Olson JM, László R, Klekner A, Zitterbart K, Phillips JJ, Thompson RC, Cooper MK, Rubin JB, Liau LM, Garami M, Hauser P, Li KKW, Ng H-K, Sang Poon W, Gillespie GY, Chan JA, Jung S, McLendon RE, Thompson EM, Zagzag D, Vibhakar R, Ra YS, Garre ML, Schüller U, Shofuda T, Faria CC, López-Aguilar E, Zadeh G, Hui CC, Ramaswamy V, Bailey SD, Jones SJM, Mungall AJ, Moore RA, Calarco J, Stein L, Bader GD, Reimand J, Ragoussis J, Weiss WA, Marra MA, Suzuki H, Taylor MD*, The Transcriptome of Sonic Hedgehog Medulloblastoma. Nature Communications 2021;12(1):1749. | PMID: 33741928 | DOI : 10.1038/s41467-021-21883-0

Huang M†, Tailor J, Zhen Q, Gillmor AH, Miller ML, Weishaupt H, Chen J, Zheng T, Nash EK, McHenry LK, An Z, Ye F, Takashima Y, Clarke J, Ayetey H, Cavalli FMG, Luu B, Moriarity BS, Ilkhanizadeh S, Chavez L, Yu C, Kurian KM, Magnaldo T, Sevenet N, Koch P, Pollard SM, Dirks P, Snyder MP, Largaespada DA, Cho YJ, Phillips JJ, Swartling FJ, Morrissy AS, Kool M, Pfister SM, Taylor MD, Smith A, Weiss WA*, Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis. Cell Stem Cell 2019;25(3):433-446.e7. | PMID: 31204176 | DOI : 10.1016/j.stem.2019.05.013

Hoffman M†, Gillmor AH, Kunz DJ, Johnston MJ, Nikolic A, Narta K, Zarrei M, King J, Ellestad K, Dang NH, Cavalli FMG, Kushida MM, Coutinho FJ, Zhu Y, Luu B, Ma Y, Mungall AJ, Moore R, Marra MA, Taylor MD, Pugh TJ, Dirks PB, Strother D, Lafay-Cousin L, Resnick AC, Scherer S, Senger DL, Simons BD, Chan JA, Morrissy AS, Gallo M*, Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma. Cancer Res 2019;79(9):2111-2123. | PMID: 30877103 | DOI : 10.1158/0008-5472.CAN-18-3441

Johnston MJ†, Nikolic A, Ninkovic N, Guilhamon P, Cavalli FMG, Seaman S, Zemp FJ, Lee J, Abdelkareem A, Ellestad K, Murison A, Kushida MM, Coutinho FJ, Ma Y, Mungall AJ, Moore R, Marra MA, Taylor MD, Dirks PB, Pugh TJ, Morrissy AS, St Croix B, Mahoney DJ, Lupien M, Gallo M*, High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma. Genome Res 2019;29(8):1211-1222. | PMID: 31249064 | DOI : 10.1101/gr.246520.118

Garzia L†, Kijima N†, Morrissy AS†, Wu X, Wang X, Donovan LK, De Antonellis P, Liu K-W, Luu B, Alamsahebpour A, Thompson YY, Holgado BL, Ramaswamy V, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Manno A, Liu J, Qin L, Cybulsky M, Mitra S, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Bouffet E, Sorensen PHB, Aldape K, Marra MA, Wechsler-Reya RJ, Fults DW, Taylor MDP*, A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell 2018;172(5):1050-1062.e14. | PMID: 29474906 | DOI : 10.1016/j.cell.2018.01.038

Northcott PA†, Buchhalter I†, Morrissy AS†, Hovestadt V, Groebner S, Ehrenberger T, Segura-Wang M, Zichner T, Weischenfeldt J, Schumacher S, Phillips AH, Kleinheinz K, Waszak SM, Erkek A, Jones DTW, Worst BC, Kool M, Zapatka M, Jäger N, Chavez L, Hutter B, Bieg M, Paramasivam N, Heinold M, Gu Z, Warnatz H-J, Risch T, Amstislavskiy V, Weber U, Wolf S, Robinson GW, Zhou X, Wu G, Finkelstein D, Cavalli FMG, Luu B, Ramaswamy V, Wu X, Koster J, Ryzhova M, Cho Y-J, Pomeroy S, Herold-Mende S, Schuhmann M, Ebinger M, Liau LM, Mora J, McLendon RE, Jabado N, Kumabe T, Witt O, Milde T, Von Deimling A, Capper D, Korshunov A, Yaspo M-L, Kriwacki R, Gajjar A, Zhang J, Beroukhim R, Fraenkel E, Korbel JO, Brors B, Schlesner M, Eils R, Marra MA, Pfister SM, Taylor MD, and Lichter P*, The whole-genome landscape of medulloblastoma subtypes. Nature 2017;547(7663):311-317. | PMID: 28726821 | DOI : 10.1038/nature22973

Morrissy AS†, Remke M†, Cavalli FMG†, Ramaswamy V, Shih DJH, Agnihotri S, Kiehna EN, Mercier E, Mayoh C, Papillon- Cavanagh S, Nikbakht H, Gayden T, Torchia J, Picard D, Merino D, Horswell S, Luu B, Wu X, Yao Y, Hovestadt V, Northcott PA, Jones DTW, Peacock J, Garzia L, Wang X, Mack SC, Reimand J, Albrecht S, Fontebasso AM, Thiessen N, Li Y, Schein JE, Lee D, Carlsen R, Mayo M, Tse K, Tam A, Dhalla N, Ally A, Chuah E, Cheng Y, Plettner P, Li HI, Corbett R, Wong T, Long W, Loukides J, Buczkowicz P, Hawkins CE, Tabori U, Rood BR, Myseros JS, Packer RJ, Korshunov A, Lichter P, Kool M, Pfister SM, Schüller U, Dirks P, Huang A, Bouffet E, Rutka JT, Bader GD, Swanton C, Ma Y, Moore RA, Mungall AJ, Majewski J, Jones SJM, Das S, Malkin D, Jabado N, Marra MA, Taylor MD*, Spatial Heterogeneity in Medulloblastoma. Nat Genet 2017;49(5):780-788. | PMID: 28394352 | DOI : 10.1038/ng.3838

Morrissy AS†, Garzia L†, Shih DJH, Zuyderduyn S, Huang X, Skowron P, Remke M, Cavalli FMG, Ramaswamy V, Lindsay P, Jelveh S, Donovan LK, Wang X, Luu B, Zayne K, Li Y, Mayoh C, Thiessen N, Mercier E, Mungall KL, Yusanne M, Tse K, Zeng T, Shumansky K, Roth AJL, Shah S, Farooq H, Kijima N, Holgado BL, Lee JJY, Matan-Lithwick S, Liu J, Mack SC, Manno A, Michaelraj KA, Nor C, Peacock J, Qin L, Reimand J, Rolider A, Thompson YY, Wu X, Pugh T, Ally A, Bilenky M, Butterfied YSN, Carlsen R, Cheng Y, Chuah E, Corbett RD, Dhalla N, He A, Lee D, Li HI, Long W, Mayo M, Plettner P, Qian JQ, Schein JE, Tam A, Wong T, Birol I, Zhao Y, Faria CC, Pimentel J, Bendel AE, Fults DW, Walter AW, Kumabe T, Tominaga T, Collins VP, Cho YJ, Hoffman C, Lyden D, Wisoff J, Garvin JH, Stearns DS, Massimi L, Schuller U, Sterba J, Zitterbart K, Puget S, Ayrault O, Dunn SE, Tirapelli DPC, Carlotti CG, Wheeler H, Hallahan AR, Ingram W, MacDonald TJ, Olson JJ, Van Meir EG, Lee JY, Wang KC, Kim SK, Cho BK, Marra MA, Taylor MD*, Divergent clonal selection dominates medulloblastoma at recurrence. Nature 2016;529(7586):351-7. | PMID: 26760213 | DOI : 10.1038/nature16478