Software

mosaicMPI: mosaic multi-resolution program integration

mosaicMPI is a Python package enabling mosaic integration of bulk, single-cell, and spatial expression data through program-level integration. Programs are first discovered using consensus non-negative matrix factorization and then integrated using a flexible network-based approach to group similar programs together across resolutions and datasets. Program communities are then interpreted using sample/cell metadata and classical gene set analyses. Integrative program communities enable metadata transfer across datasets.

https://github.com/MorrissyLab/mosaicMPI

by Theodore B. Verhey